Protective compounds of tardigrades discovered in laboratory and space projects

Authors

  • Luis Alberto Allccahuaman Huauya Universidad Peruana Cayetano Heredia, Lima, Perú Author

DOI:

https://doi.org/10.69976/aspast.v2n1.3

Keywords:

Tardigrada, Extremophile, Resistance, Bioprotection

Abstract

Tardigrades are animals of interest in Astrobiology and are used as a model for the evaluation of life resistance. The aim of the present work is to detail the bioprotectants of tardigrades, based on space projects and their compromising applications. A search on space projects using tardigrades was carried out and 50 scientific articles were selected. The TARSE Project and TARDIKISS determined antioxidant compounds (superoxide dismutase, peroxidase, catalase and glutathione peroxidase), DNA Associated Protein and Thermal Shock Protein. In conclusion, the bioprotectants enabled resistance to space and would be useful in agriculture, space medicine, space travel and regenerative medicine.

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Author Biography

  • Luis Alberto Allccahuaman Huauya, Universidad Peruana Cayetano Heredia, Lima, Perú

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References

Clark-Hachtel, C. M., Hibshman, J. D., Buysscher, T. D., & Goldstein, B. (2023). Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation. En bioRxiv. https://doi.org/10.1101/2023.09.07.556677

Coleine, C., Pombubpa, N., Zucconi, L., Onofri, S., Stajich, J. E., & Selbmann, L. (2020). Endolithic fungal species markers for harshest conditions in the McMurdo dry valleys, Antarctica. Life, 10(2), 1-12. https://doi.org/10.3390/life10020013

Greven, H. (2018). From Johann August Ephraim Goeze to Ernst Marcus: A Ramble Through the History of Early Tardigrade Research (1773 Until 1929). En R. Schill (Ed.). Water Bears: The Biology of Tardigrades (pp. 1–55). Springer International Publishing. https://doi.org/10.1007/978-3-319-95702-9_1

Guidetti, R., Altiero, T., & Rebecchi, L. (2011). On dormancy strategies in tardigrades. Journal of Insect Physiology, 57(5), 567–576. https://doi.org/10.1016/j.jinsphys.2011.03.003

Heidemann, N. W. T., Smith, D. K., Hygum, T. L., Stapane, L., Clausen, L. K. B., Jørgensen, A., Hélix-Nielsen, C., & Møbjerg, N. (2016). Osmotic stress tolerance in semi-terrestrial tardigrades. Zoological Journal of the Linnean Society, 178(4), 912–918. https://doi.org/10.1111/zoj.12502

Hibshman, J. D., Carra, S., & Goldstein, B. (2023). Tardigrade small heat shock proteins can limit desiccation-induced protein aggregation. Communications Biology, 6, 1-10. https://doi.org/10.1038/s42003-023-04512-y

Hu, C., Yang, J., Qi, Z., Wu, H., Wang, B., Zou, F., Mei, H., Liu, J., Wang, W., & Liu, Q. (2022). Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities. MedComm, 3(3), 1-39. https://doi.org/10.1002/mco2.161

Jönsson, K. I., & Schill, R. O. (2007). Induction of Hsp70 by desiccation, ionising radiation and heat-shock in the eutardigrade Richtersius coronifer. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 146(4), 456–460. https://doi.org/10.1016/j.cbpb.2006.10.111

Jönsson, K. I., Rabbow, E., Schill, R. O., Harms-Ringdahl, M., & Rettberg, P. (2008). Tardigrades survive exposure to space in low Earth orbit. Current biology: CB, 18(17), 729–731. https://doi.org/10.1016/j.cub.2008.06.048

Johnson, A. P., Pratt, L. M., Vishnivetskaya, T., Pfiffner, S., Bryan, R. A., Dadachova, E., Whyte, L., Radtke, K., Chan, E., & Tronick, S. (2011). Extended survival of several organisms and amino acids under simulated martian surface conditions. Icarus, 211(2), 1162–1178. https://doi.org/10.1016/j.icarus.2010.11.011

Jönsson, K. I. (2019). Radiation tolerance in tardigrades: Current knowledge and potential applications in medicine. Cancers, 11(9), 1-15. https://doi.org/10.3390/cancers11091333

Kasianchuk, N., Rzymski, P., & Kaczmarek, Ł. (2023). The biomedical potential of tardigrade proteins: A review. Biomedecine & Pharmacotherapie, 158(114063), 1-11. https://doi.org/10.1016/j.biopha.2022.114063

Kirke, J., Jin, XL. & Zhang, XH. (2020) Expression of a Tardigrade Dsup Gene Enhances Genome Protection in Plants. Mol Biotechnol 62, 563–571. https://doi.org/10.1007/s12033-020-00273-9

Lim, S., Reilly, C. B., Barghouti, Z., Marelli, B., Way, J. C., & Silver, P. A. (2024). Tardigrade secretory proteins protect biological structures from desiccation. Communications Biology, 7, 1-10. https://doi.org/10.1038/s42003-024-06336-w

May R, Maria M, Guimard J. (1964). Actions différentielles des rayons x et ultraviolets sur le tardigrade Macrobiotus areolatus. S l’état et desséché Bull Biol France Belgique, 98, 349–367.

Mínguez-Toral, M., Cuevas-Zuviría, B., Garrido-Arandia, M., & Pacios, L. F. (2020). A computational structural study on the DNA-protecting role of the tardigrade-unique Dsup protein. Scientific Reports, 10, 1-18. https://doi.org/10.1038/s41598-020-70431-1

Møbjerg, N., & Neves, R. C. (2021). New insights into survival strategies of tardigrades. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 254(110890), 1-6. https://doi.org/10.1016/j.cbpa.2020.110890

Neves, R. C., Hvidepil, L. K. B., Sørensen-Hygum, T. L., Stuart, R. M., & Møbjerg, N. (2020). Thermotolerance experiments on active and desiccated states of Ramazzottius varieornatus emphasize that tardigrades are sensitive to high temperatures. Scientific Reports, 10, 1-12. https://doi.org/10.1038/s41598-019-56965-z

Orellana, R., Macaya, C., Bravo, G., Dorochesi, F., Cumsille, A., Valencia, R., Rojas, C., & Seeger, M. (2018). Living at the frontiers of life: Extremophiles in Chile and their potential for bioremediation. Frontiers in microbiology, 9, 1- 25. https://doi.org/10.3389/fmicb.2018.02309

Persson, D., Halberg, K. A., Jørgensen, A., Ricci, C., Møbjerg, N., & Kristensen, R. M. (2011). Extreme stress tolerance in tardigrades: surviving space conditions in low earth orbit. Journal of Zoological Systematics and Evolutionary Research, 49, 90–97. https://doi.org/10.1111/j.1439-0469.2010.00605.x

Rebecchi, L., Altiero, T., Guidetti, R., Cesari, M., Bertolani, R., Negroni, M., & Rizzo, A. M. (2009). Tardigrade Resistance to Space Effects: first results of experiments on the LIFE-TARSE mission on FOTON-M3 (September 2007). Astrobiology, 9(6), 581–591. https://doi.org/10.1089/ast.2008.0305

Ricci, C., Riolo, G., Marzocchi, C., Brunetti, J., Pini, A., & Cantara, S. (2021). The tardigrade damage suppressor protein modulates transcription factor and DNA repair genes in human cells treated with hydroxyl radicals and UV-C. Biology, 10, 1-14. https://doi.org/10.3390/biology10100970

Rizzo, A. M., Altiero, T., Corsetto, P. A., Montorfano, G., Guidetti, R., & Rebecchi, L. (2015). Space flight effects on antioxidant molecules in dry tardigrades: The TARDIKISS experiment. BioMed Research International, 1–7. https://doi.org/10.1155/2015/167642

Sadowska-Bartosz, I., & Bartosz, G. (2024). Antioxidant defense in the toughest animals on the earth: Its contribution to the extreme resistance of tardigrades. International Journal of Molecular Sciences, 25(15), 8393. https://doi.org/10.3390/ijms25158393

Saigo, T., Satoh, K., & Kunieda, T. (2024). Comparative study of gamma radiation tolerance between desiccation-sensitive and desiccation-tolerant tardigrades. En bioRxiv. https://doi.org/10.1101/2024.06.26.600756

Weronika, E., & Łukasz, K. (2017). Tardigrades in Space Research - Past and Future. Origins of life and evolution of the biosphere: the journal of the International Society for the Study of the Origin of Life, 47(4), 545–553. https://doi.org/10.1007/s11084-016-9522-1

Wilanowska, P., Rzymski, P., & Kaczmarek, Ł. (2024). Long-term survivability of tardigrade Paramacrobiotus experimentalis (eutardigrada) at increased magnesium perchlorate levels: Implications for astrobiological research. Life, 14(3), 1-10. https://doi.org/10.3390/life14030335

Ye, C., Guo, J., Zhou, X. Q., Chen, D. G., Liu, J., Peng, X., Jaremko, M., Jaremko, Ł., Guo, T., Liu, C. G., & Chen, K. (2023). The Dsup coordinates grain development and abiotic stress in rice. Plant physiology and biochemistry: PPB, 205, 108184. https://doi.org/10.1016/j.plaphy.2023.108184

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Published

2025-06-30

How to Cite

Allccahuaman Huauya, L. A. (2025). Protective compounds of tardigrades discovered in laboratory and space projects. Scientific Journal of Astrobiology, 2(1), 32-39. https://doi.org/10.69976/aspast.v2n1.3